--- scripts/python/setup.py
+++ scripts/python/setup.py
@@ -15,9 +15,7 @@
 
 obExtension = Extension('_openbabel',
                  [os.path.join(srcdir, "openbabel-python.cpp")],
-                 include_dirs=[os.path.join(srcdir, "..", "..", "include"),
-                               os.path.join("..", "include")],
-                 library_dirs=[os.path.join("..", "lib")],
+                 include_dirs=[os.path.join("/usr", "include", "openbabel-2.0")],
                  libraries=['openbabel']
                  )