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diff --git a/sci-biology/meme/meme-4.8.1-r2.ebuild b/sci-biology/meme/meme-4.8.1-r2.ebuild
new file mode 100644
index 000000000000..abc810087e9a
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+++ b/sci-biology/meme/meme-4.8.1-r2.ebuild
@@ -0,0 +1,85 @@
+## Copyright 1999-2011 Gentoo Foundation
+# Distributed under the terms of the GNU General Public License v2
+# $Header: /var/cvsroot/gentoo-x86/sci-biology/meme/meme-4.8.1-r2.ebuild,v 1.1 2013/03/01 12:43:54 jlec Exp $
+
+EAPI=4
+
+PYTHON_DEPEND="2"
+
+inherit autotools eutils python
+
+DESCRIPTION="The MEME/MAST system - Motif discovery and search"
+HOMEPAGE="http://meme.sdsc.edu/meme"
+SRC_URI="http://meme.nbcr.net/downloads/${PN}_${PV}.tar.gz"
+
+LICENSE="meme"
+SLOT="0"
+KEYWORDS="amd64 x86"
+IUSE="debug examples mpi"
+
+DEPEND="
+	app-shells/tcsh
+	dev-libs/libxml2:2
+	dev-libs/libxslt
+	mpi? ( virtual/mpi )"
+RDEPEND="${DEPEND}"
+
+S="${WORKDIR}/${PN}_${PV}"
+
+#pkg_setup() {
+	# generate meme group to restrict logging to /var/log/meme
+#	enewgroup meme
+#	python_pkg_setup
+#	python_set_active_version 2
+#}
+
+src_prepare() {
+	use examples || sed -e '/SUBDIRS/s:examples::g' -i doc/Makefile.am
+	sed \
+		-e '/flags/s:-O3::g' \
+		-e '/opt/s:-O::g' \
+		-e '/debug/s:-ggdb::' \
+		-e '/debug/s:-g::' \
+		-e 's:CFLAGS=:CFLAGS+=:g' \
+		-i configure.ac || die
+	epatch \
+		"${FILESDIR}"/${P}-Makefile.am.patch
+	eautoreconf
+}
+
+src_configure() {
+	MY_PREFIX="${ROOT}opt/meme"
+	USE_DISABLE_MPI=""; if ! use mpi; then USE_DISABLE_MPI="--enable-serial"; fi
+	econf \
+		--sysconfdir="${EPREFIX}/etc/meme" \
+		--with-logs="${ROOT}var/log/meme" \
+		$(use_enable debug) \
+		$USE_DISABLE_MPI
+}
+
+src_test() {
+	# bug #297070
+	emake -j1 test
+}
+
+src_install() {
+	local i
+	default
+
+	for i in "${ED}"/usr/bin/*; do
+		"${ED}"/usr/bin/{,meme-}${i} || die
+	done
+
+	echo "PATH=/opt/${PN}/bin" > 99${PN}
+	doenvd 99${PN}
+
+	# allow logging only for members of meme group
+	# diropts -m 0770 -g meme -o root
+	diropts -m ugo+rwxt -o root
+	keepdir /var/log/meme
+}
+
+#pkg_postinst() {
+#	einfo 'Log files are produced in the "/var/log/meme" directory. Users'
+#	einfo 'need to be part of the meme group to use this facility.'
+#}